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20 Apr, 2014

Curriculum Vittae

Curriculum Vitae Dosen

Junaidi Khotib, S.Si, Apt., M.Kes.,PhD
Pendidikan : S.3 (PhD)
Mata Kuliah :
Farmasi Klinik

A. EDUCATION    :

Name of Institution Major Field Academic Degree Year
1. Airlangga University Pharmacy B.Sc. 1989-1994
2. Airlangga University Apotheker Apt. 1994-1995
3. Airlangga University Biochemistry M.Sc. 1995-1998
4. Hoshi University, Tokyo Pharmacology-Toxicology Ph.D 2001-2004
5. Hoshi University, Tokyo Pharmacology-Toxicology Post-doctoral 2004-2005

 

B. PENELITIAN

1.Uji mutu sediaan tablet Kotrimoksazol 400/80mg yang beredar.
2.Pengaruh pemberian B-Karoten dan kombinasi vitamin E-Vitamin C terhadap prevalensi kanker pada mencit.
3.Perencanaan pendidikan apotek.

C. PROFFESIONAL SERVICE / EMPLOYMENT :
(1). 1995-2001: Lecturer at Biopharmaceutics and Pharmacokinetics Laboratory, Faculty of Pharmacy, Airlangga University, Surabaya, East Java, Indonesia.
(2). 1995-2001: Drug Information Service at “Apotek Sepuluh Nopember” Institut Teknologi 10 Nopember Surabaya, Surabaya, East Java, Indonesia.
(3). 1997-2001: Pharmaceutical Services at Hospital, Department of Pharmacy, Soetomo Hospital, Surabaya, East Java, Indonesia.
(4). 2001-present: Lecturer at Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya, East Java, Indonesia.
(5). 2005-present: Visiting Lecture at Faculty of Pharmacy, International Islamic University Malaysia.
(6). 2007-present: Bioequivalence Studies Consultant of The National Agency of Drug and Food Control.

D. SEMINAR :
(1). Khotib, J., Narita, M., Ozaki, S., Suzuki, T. Heterologous mu-receptor modification by repeated stimulation of kappa-receptor in the mouse brain. 33rd International Narcotics Research Conference, California, July 9-14, 2002.

(2). Shimamura, M., Narita, M., Yajima, Y., Khotib, J., Kubota, C., Suzuki, T. Up-regulation of PGE2-receptor, but not PGI2- and opioid-receptors, in the mouse spinal cord following peripheral inflammation. 33rd International Narcotics Research Conference, California, July 9-14, 2002.

(3). Khotib, J., Narita, M., Suzuki, M., Ozaki, S., Suzuki, T. Heterologous m-opioid receptor modification by repeated stimulation of k-opioid receptor: Up-regulation of G-protein activation and antinociception. The 23rd Japan Narcotics Research Conference, Tokyo, August 23-24, 2002.

(4). Shimamura, M., Narita, M., Yajima, Y., Khotib, J., Kubota, C., Suzuki, T. Role of spinal COX/PG pathway in the expression of chronic inflammatory pain. 123rd The Japanese Pharmaceutical Society Meeting, Nagasaki, March 27-29, 2003.

(5). Khotib, J., Narita, M., Mizoguchi, H., Suzuki, M.,Yajima, Y., Tseng, L.F., Suzuki, T. The up-regulation of central mu-opioid receptors functions induced by repeated stimulation of kappa-opioid receptor. 34th International Narcotics Research Conference, Perpignan, France, July 11-16, 2003.

(6). Kuzumaki, N., Narita, M., Khotib, J., Kaneko. C., Miyagawa, K., Tanaka, S., Suzuki, T. Mechanism of anxiogenic effect in normal aging. 1st International Neurobehavioral Pharmacology Meeting, Okayama, September 12-15, 2003.

(7). Kuzumaki, N., Narita, M., Kaneko. C., Khotib, J., Tanaka, S., Suzuki, T. Mechanism of anxiogenic effect in normal aging. 109th Kanto Area Meeting of The Japanese Pharmacological Society, Tokyo, October 4, 2003.

(8). Khotib, J., Narita, M., Suzuki, M.,Yajima, Suzuki, T. Direct evidence for the up-regulation of central mu-opioid receptor functions induced by repeated stimulation of kappa-opioid receptor. 33th Japan Neuropsycopharmacology Meeting, Nara, October 8-10, 2003.

(9). Khotib, J., Narita, M., Niikura, K., Yajima, Suzuki, T. Studies on drug dependence (Rept. 387): Short-term up-regulation of m-opioid receptor functions after repeated administration of the k-opioid receptor agonist in the thalamus of rodents. The 77th Annual Meeting of the Japanese Pharmacological Society, Osaka, Maret 8-10, 2004.

(10). Khotib, J., Narita, M., Niikura, K., Yajima Y., Syamsiah, S., Suzuki, T. Short-termed up-regulation of mu-opioid receptor functions after repeated administration of the kappa-opioid receptor agonist in the rodent. 35th International Narcotics Research Conference, Kyoto, Japan, July 18-23, 2004.

(11). Khotib J., Narita M., Narita M., Suzuki M., Niikura K., Yajima Y., Syamsiah S and Suzuki. Studies on drug dependence (Rept. 405): Involvement of neuronal migrating regulator in the development of tolerance to morphine-induced antinciception. The 78th Annual Meeting of the Japanese Pharmacological Society, Yokohama, Maret 22-24, 2005.

(12). Usui A., Narita M., Yajima Y., Narita M., Khotib J., Suzuki T. Studies on pain control system (Rept. 34): Involvement of spinal thrombin/platelet-derived growth factor (PDGF) pathway in the development of neuropathic pain-like state. The 78th Annual Meeting of the Japanese Pharmacological Society, Yokohama, Maret 22-24, 2005.

(13). Rahmadi M., Khotib J., Suprapti B., Sjamsiah S. Antinociceptive effect of kappa-opioid receptor agonist in the acute and chronic-pain state. The 14th Annual Meeting of the Indonesia Pharmacy Association, Bali, June 17-19, 2005.

(14). Khotib J. Molecular mechanisms of development opioid-induced antinociceptive tolerance. The 14th Annual Meeting of the Indonesia Pharmacy Association, Bali, June 17-19, 2005.

(15). Khotib J., Zulkarnain BS., Yulistiani, Sjamsiah S., Suzuki T. Role of kappa opioid receptor agonist (-)U-50,488H on the attenuation of withdrawal symptoms in morphine or amphetamine induced-dependence. The 14th Annual Meeting of the Indonesia Pharmacy Association, Bali, June 17-19, 2005.

(16). Khotib J., Zulkarnain BS., Analgetics. National Seminar and Pharmacotherapy Update, Surabaya, January 16-17, 2007

(17). Khotib J, Kusumawati I., Rahmadi M., Zulkarnain BS., Dyatmiko W., Supraspinal antinociceptive activity of ethanol extract of Kaemferia galanga Linn rhizomes and Sida rhombifolia L herbs. The IOCD International Symposium, Surabaya, April 8-11, 2007

(18). Khotib J, Budiatin AS, The effectiveness of a diseased-animal model for study of drug potency in the pathology-like state, Kongres Ilmiah XV ISFI, Jakarta, June 17-19, 2007

(19). Khotib J, Aryani T, Samirah, Molecular mechanism of a selective kappa opioid receptor agonist on the attenuation of morphine-induced withdrawal syndrome, Kongres Ilmiah XV ISFI, Jakarta, June 17-19, 2007

(20). Khotib J, Yulistiani, Dimas F, Asih D, Martiniani E, Semedi J and Syamsiah S. Drug utilization study in hospitalized patients with pulmonary tuberculosis at the state hospital in Surabaya, The 7th ASEAN Conference on Clinical Pharmacy, Shanghai, July 6-9, 2007

(21). Khotib J, Narita M, Aryani T, Syamsiah S and Suzuki T, Molecular mechanism of development of morphine-induced antinociceptive tolerance, , The 7th ASEAN Conference on Clinical Pharmacy, Shanghai, July 6-9, 2007
(22). Jayaputra V, Khotib J, Involvement of Mitogen Activated Protein (MAP) Kinase in the Development of Neuropathic Pain-Like State, USM-UNAIR First Collaborative Conference, Penang, 13-14 June 2007
(23). Apryani E, Khotib J, Pivotal Role reelin Signaling Pathway in the Development of Tolerance to Morphine Induced Antinociception, USM-UNAIR First Collaborative Conference, Penang, 13-14 June 2007
(24). Khotib J, Inactivation of protein Tyrosine Phosphatase (PTP-ase) linked Insulin Receptor Mediated the Hypoglycemic Effect of Vanadyl Sulfate, The 8th  Asian Conference on Clinical Pharmacy, Surabaya, 1-4 July 2008.
(25). Khotib J, Drug Utilization Study of Hospitalized Patient with Colorectal Cancer, USM-UNAIR First Collaborative Conference, Surabaya, 10-11 February 2009

E.    RESEARCH GRANT :
(1). Quality assurance of mefenamic acid 500 mg tablet in market, Young Researcher Grant, 1999/2000
(2). Quality assurance of combination sulphametoxazole and trimetophrim 400/80 mg in market, Young Researcher Grant, 1999/2000
(3). Effectiveness of an antidiabetic vanadyl sulphate in the lowering glucose concentration diabetic-mice, DIP A PNBP, 2005
(4). Involvement of tyrosin kinase in the development of tolerance to opioid-induced antinciception DIP A PNBP, 2005
(5) Antinociceptive effect of GABA agonist gabapentine in the neuropathic pain treatment in animal model, DIP A PNBP Unair, 2005
(6). Bioavailability and bioekivalence of risendronate 35 mg tablet, Kalbe Farma, 2005
(7) Mekanisme molekuler efek analgesik selektif agonis reseptor opioid kappa (-)U50,488H, DIPA PNBP Unair, 2005
(8) Bioavailability and bioequivalence of levofloxacine 500 mg tablet, Kimia Farma, 2006
(9) Cancer Model, BPPT, 2007-2009
(10) Prospek vanadium sebagai antidiabetik oral yang poten melalui penghambatan aktivitas tirosin kinase, Hibah Bersaing, 2008
(11) Peran Neuronal Migrating Factor pada Perkembangan Toleransi Analgesik, Strategis Nasional, 2009

F. PUBLICATION :
1). Narita, M., Mizoguchi, H., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y., Narita, M., Tseng, L.F. and Suzuki, T. (2002) Influence of a deletion of protein kinase Cg isoform in the G-protein activation mediated through opioid receptor-like-1 and m-opioid receptors in the mouse pons/medulla. Neurosci. Lett. 331, 5-8.

(2). Narita, M., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y. and Suzuki, T. (2003) Heterologous m-opioid receptor adaptation by repeated stimulation of k-opioid receptor: up-regulation of G-protein activation and antinociception, J. Neurochem. 85, 1171-1179.

(3). Narita, M., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y., Mizoguchi, H., Tseng, L.F. and Suzuki, T. (2003) Direct evidence for the up-regulation of spinal m-opioid receptor after repeated stimulation of k-opioid receptors in the mouse. Eur. J. Neurosci. 18, 2498-2504.

(4). Khotib, J., Narita, M., Suzuki, M., Yajima, Y. and Suzuki, T. (2003) Studies on drug dependence (Rept. 381): Direct evidence for the up-regulation of central m-opioid receptor functions induced by repeated stimulation of k-opioid receptors. Japanese J. Neuropsycopharmacol. 23:318.

(5). Khotib, J., Narita, M., Suzuki, M., Yajima, Y. and Suzuki, T. (2004) Functional interaction among opioid receptor types: up-regulation of m- and d-opioid receptor functions after repeated stimulation of k-opioid receptors. Neuropharmacology 46, 531-540.

(6). Ozaki, S., Narita, M., Narita, M., Ozaki, M., Khotib, J. and Suzuki, T. (2004) Role of extracellular signal-regulated kinase (ERK) in the ventral tegmental area (VTA) in the suppression of the morphine-induced rewarding effect in mice with sciatic nerve ligation. J. Neurochem. 88, 1389-1397.

(7). Khotib, J., Narita, M., Niikura, K., Yajima, Y. and Suzuki T. (2004) Studies on drug dependence (Rept. 387): Short-term Short-term up-regulation of m-opioid receptor functions after repeated administration of k-opioid receptor agonist (-)U-50,488H in the thalamus of rodents, J. Pharmacological Sci. 94(supp):227P

(8). Khotib, J., Narita, M., Niikura, K., Suzuki, M., Yajima, Y. and Suzuki T. (2005) Studies on drug dependence (Rept. 405): Involvement of neuronal migrating regulator in the development of tolerance to morphine-induced antinociception, J. Pharmacological Sci. 97(supp):96P

(9). Usui, A., Narita, M., Yajima, Y.., Khotib, J., Narita, M., and Suzuki T. (2005) Studies on pain control system (Rept. 34): A protease-activated receptor-1/platelet-derived growth factor pathway in spinal cord neurons in implicated in neuropathic pain after nerve injury, J. Pharmacological Sci. 97(supp):137P

(10)    Suzuki T, Nurrochmad A, Ozaki M, Khotib J, Nakamura A, Imai S, Shibasaki M, Yajima Y, Narita M (2005) Efect of a selective GABAB receptor agonist baclofen on the m-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects, Neuropharmacology 49: 1121-1131.

(11)    Narita M, Nagumo Y, Shindo K, Narita M, Khotib J, Shibasaki M, Yanagisawa M, Nakamachi K, Shioda N, Suzuki T (2005) Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine, J Neurosci. 26(2):398-405.

(12)    Narita M, Usui , Khotib J, Narita M, Nagumo Y, Niikura K, Suzuki M, Yajima Y, Suzuki T (2005) A protease-activated receptor-1/platelet-derived growth factor pathway in spinal cord neurons is implicated in neuropathic pain after nerve injury, J. Neurosci, 25 (43): 10000-10009

(13)    Narita M, Kuzumaki N, Narita M, Kaneko C, Tamai E, Khotib J, Miyatake M, Shindo K, Nagumo Y, Tanaka S, Suzuki T. (2006) Age-related emotionality is associated with cortical delta-opioid receptor dysfunction-dependent astrogliosis. Neuroscience 137: 1359-1367.

(14)    Hasmono D, Ariyanto AN, Khotib J., (2005) Role of a protein tyrosin phosphatase in the decreasing of blood glucose level in streptozotocin-induced diabetic mice. Airlangga Journal of Pharmacy 5 (2): 35-38

(15)    Khotib J., Irawati D., Pambudi P., Aryani T., (2006) The prospective of a typical dopamine antagonist in the attenuation of morphine-induced withdrawal syndrome. Airlangga Journal of Pharmacy 5 (2): 39-44

(16)    Khotib, J., Narita, M., Narita, M., Niikura, K., Yajima, Y. and Suzuki T. (2008) Reversible up-regulation of m-opioid receptor functions after repeated administration of k-opioid receptor agonist (-)U-50,488H in the thalamus of rodents. Neuroscience, Submitted.

(17)    Khotib J, Narita M, Narita M, Suzuki M, Niikura K, Kazuyuki I, Syamsiah S and Suzuki T (2008) Involvement of neuronal migrating regulator reelin in the development of tolerance to morphine-induced antinciception. J. Neurochem. Submitted

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